Measure and modulate the sleeping brain, in your indication.
Closed-loop auditory stimulation
A non-invasive sleep modulation platform targeting disease modification, from neurodegeneration to mood disorders.
A non-invasive platform for sleep targeted neuromodulation
The AXORA headband captures medical-grade EEG and uses closed-loop algorithms to detect target sleep stages and deliver auditory stimuli via built-in headphones. This enables targeted modulation of sleep features, such as slow-wave activity.
Wavescope manages your study end to end: participant and device management, double-blinded sham-controlled study setup, automated data quality checks, and full raw EEG data access, all in one place.
Complete system
Long-term wear
Stimulation protocol
End-to-end support
TOSOO AXORA
Closed-loop auditory stimulation
Clinical applications
400+ patients across active trials in Parkinson's and Alzheimer's disease
slow-wave modulation via closed-loop auditory stimulation,
investigated as a disease-modifying intervention.
Therapeutic Potential of deep sleep
Why we target
slow-wave sleep
What is Deep Sleep?
Deep sleep, defined by slow-wave activity, drives essential restorative functions across the entire body and brain, ranging from memory consolidation and emotional regulation to immunological processing, metabolic regulation, and the clearance of neurotoxic proteins
Relevance of Deep Sleep
A bidirectional relationship exists between sleep disturbances and disease progression. In neurodegeneration, disrupted sleep worsens cognitive and motor decline. Reduced slow-wave sleep also contributes to psychiatric, neurodevelopmental, cardiovascular, and metabolic disorders such as depression, PTSD, ADHD, and diabetes.
Deep Sleep as Therapeutic Target
As slow waves emerge as a vital therapeutic target, the AXORA® neuromodulation platform provides researchers with a unique opportunity to investigate novel, non-pharmacological, and disease-modifying interventions across a broad spectrum of clinical indications.
How Axora works
Our neuromodulation platform works by continuously monitoring brain activity to detect deep sleep, then delivering brief, non-arousing auditory stimuli precisely synchronised to slow-wave activity, modulating them without disrupting sleep.
Detect Slow-Wave Activtiy
AXORA® uses medical-grade EEG to capture the synchronized firing of neurons in real time, detecting the large-amplitude oscillations known as slow waves.
Stimulate at the Right Moment
Using real-time signal processing and advanced algorithms, the system delivers brief, non-arousing acoustic pulses through the integrated earphones, precisely timed to the right phase of each slow wave.
Unlock Benefits
This phase-targeted stimulation boosts slow-wave activity, driving neurophysiological functions like memory consolidation, synaptic plasticity, and the glymphatic clearance of neurotoxic proteins.
15+
Peer-reviewed publications
across indications
10+
Ongoing studies
across indications
2000+
Stimulations
per night
60’000+
Hours of
data recorded
Past Research
A platform
validated by science
Selected publicly available closed loop auditory stimulation studies conducted using our devices. Contact us directly to learn more about ongoing studies.
General
Title
TOSOO Device
General
2026, Horlacher J et al.
npj Parkinson's Disease
10.21203/rs.3.rs-7829414/v1
Preprint
Title
Home-Based Deep Sleep Modulation in Parkinson's Disease: Extension Study on Long-Term Feasibility and Sleep-Related Outcomes
Clinical & Translational Studies
TOSOO Device
General
2025, Schreiner S et al.
Medrxiv
10.1101/2025.01.30.25320306
Preprint
Title
Auditory Enhancement of Sleep Slow Waves in People with Parkinson's Disease: A Proof-of-Concept Study
Clinical & Translational Studies
TOSOO Device
General
2025
Kasties V et al.
Sleep Advances
10.1093/sleepadvances/zpaf073
Title
Optimizing Automated Phase-Targeted Auditory Stimulation Protocols for Procedural Memory Consolidation During Sleep in a Home Setting
Clinical & Translational Studies
TOSOO Device
Dropout rate
Data capture rate
Rated the device easy to use
Serious adverse events
Device Evolution
Backed by years
of research
Our technology has been stress-tested across populations, settings, and hardware generations.
AXORA is a complete sleep platform integrating Wavescope, our study management software, and the TOSOO Connect patient app. A wet electrode setup delivers high-accuracy EEG data in a lightweight, minimal fabric design built for long-term nightly wear.
The TSB Axo marked the transition from academic instrument to engineered product, with a streamlined wearable form factor, reduced energy consumption, and improved stimulation algorithms and protocols.
The v3 introduced a smaller, more comfortable form factor for nightly use and integration with a third-party data management system.
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The SleepBand v2 was our first device deployed in active research, bringing closed-loop auditory stimulation from concept into practice and establishing the scientific foundation we build on today.
Our journey began with the SleepLoop Consortium's vision: to enhance sleep through cutting-edge technology. Developed at ETH Zurich and the University of Zurich, it was the first proof that closed-loop auditory stimulation could work.
Request AXORA
Tell us about your research and we'll get back to you.
Frequently Asked Questions
Our standard protocol is optimized for slow-wave activity. However, the AXORA platform is customizable; we can develop bespoke protocols for other types of modulation depending on your specific research requirements.
Yes. We offer multiple sizes designed for ergonomic comfort across a wide demographic, including pediatric sizes.
No. Our closed-loop auditory stimulation is delivered at sub-awakening thresholds, ensuring the patient remains in deep sleep while their brain activity is enhanced.
Yes. Beyond standard pink noise, the platform has been used in studies delivering complex stimuli, such as verbal cues for memory reactivity.
Absolutely. Our technology is designed for longitudinal interventions of 18+ months. We report exceptionally low dropout rates, proving the device is suitable for consistent, nightly home use.
We typically operate on a rental model. Pricing is tiered based on the duration of your intervention and the total number of headbands required for your cohort.
Yes. We offer end-to-end support, including ethics application guidance, study design, and potential co-authorship. Support levels are tailored to the specific needs of each individual case.
Currently, AXORA is available for research and clinical use only. However, you may be eligible to participate in one of our ongoing studies.
Not yet. We are currently undergoing the regulatory pathways for medical certification. At present, it is designated for clinical research and investigational use.
Yes, we welcome new collaborations. Due to high demand, it is helpful if you have an initial draft of your study protocol or a specific hypothesis ready for our team to review.